LGD-4033 is a selective androgen receptor modulator (SARM). LGD-4033 binds to the androgen receptor of muscle and bone selectively, exhibiting similar effects as testosterone, with only partial agonist activity on the prostate. It was developed as a way to treat diseases or conditions associated with muscle and bone deterioration. The advantage a SARM like LGD has over testosterone is the difference in activity it has on the body outside of muscle and bone.
LGD-4033as a significant effect on building lean muscle mass, strengthening bone and muscle, and it even has potential to help with healing. This is the most anabolic of SARMS, but, just like its cousins andarine and mk-2866, it binds very strongly to the androgen receptor. However, it favors the receptors in your muscle and bone, causing anabolic and anti-catabolic effects. In addition, it has a significant effect in preventing bone degeneration, and it has even proven to strengthen bones with minimized risk of typical androgenic problems like prostate enlargement, hair loss, etc.
In one study, male rats were castrated and left untreated for 14 days to allow for muscle and prostate to atrophy. These rats were then treated with LGD-4033 after 14 days and showed potent activity in the skeletal muscle, but very weak activity in the prostate despite higher concentrations being found there. Another study, conducted by Ligand over a 28 day period, showed that increased muscle mass in female rats was related to an increase in the muscle fibre cross sectional diameter due to LGD-4033 use.
LGD-4033, like other popular SARMS, is very versatile and has a list of benefits no matter the goal of the user. Whether it’s lean muscle mass, maintenance of your hard earned gains during a cutting cycle, or bridging the gap between steroid cycles, LGD-4033 can be a very beneficial tool. Studies suggest that this SARM will lend therapeutic benefit to many testosterone deficiency conditions. In fact, it’s not unheard of to hear of improvements in joint pain or nagging injuries after starting a course of LGD-4033, much like its cousin Ostarine. In addition, LGD-4033 can increase strength, vascularity, and fat loss while bulking, and it can help during “recomposition”.
Reports of increased endurance is common and when stacked with Cardarine, and the level it increases will blow your socks off. Actually, LGD-4033 can be stacked quite well with any of the popular SARMS. In fact, it creates the perfect anabolic storm of lean muscle and fat loss when stacked with all 3 sarms, and it can be stacked safely, with minimal suppression.
LGD-4033 has virtually no side effects. With no significant activity in the prostate, and no liver toxicity whatsoever, this SARM does cause dose related hormone suppression. A slight decrease in total and free testosterone, as well as SHBG has been displayed with LGD, but neither LH nor FSH showed any decrease whatsoever.
LGD-4033 is most commonly recommended at 5-10mg per day with once daily dosing schedule. The half-life of LGD is between 24-36hrs. It has been found to be well tolerated at up to 22mg/day in people.
LGD-4033 is unarguably the strongest SARM on the market today as far as anabolic power. It adds extra muscle building power to a cutting cycle, strength and size to a bulking cycle, and resilience for the endurance athlete. Used by itself or stacked with one or more other compounds, LGD-4033 demands recognition in the world of health, fitness, and bodybuilding.